Phytosterol capsules and serum cholesterol in hypercholesterolemia: A randomized controlled trial

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• 作者：Inger Ottestad^a ; ^b ; ¹ ; Leiv Ose^c ; ^{leiv.ose@oslo-universitetssykehus.no} ; ^{leiv.ose@klinmed.uio.no} ; ^{lose@ous-hf.no} ; Marianne H. Wennersberg^d ; ¹ ; Linda Granlund^e ; ³ ; Bente Kirkhus^f ; ² ; ⁴ ; Kjetil Retterst&oslash ; l^c ; ^b
• 关键词：Capsules ; Cholesterol ; Hypercholesterolemia ; Pharmacology ; Phytosterol ; Dietary supplement
• 刊名：Atherosclerosis
• 出版年：2013
• 出版时间：June, 2013
• 年：2013
• 卷：228
• 期：2
• 页码：421-425
• 全文大小：199 K

文摘

Objective

Phytosterols are recommended in combination with diet therapy to reduce elevated LDL-cholesterol level. Meta-analyses indicate a 10 % reduction in LDL-cholesterol from intake of approximately 2?g phytosterols/d incorporated into fat-based foods. However, the cholesterol lowering effect from capsules containing phytosterols is less documented. The pre-specified primary endpoint of the present study was to investigate the effect of capsules with phytosterols on circulating LDL-cholesterol in patients with mild to moderate hypercholesterolemia.

Methods

In a double-blinded, randomized, placebo-controlled crossover study, 41 men and women were randomized into two four-weeks intervention periods with softgel capsules containing either phytosterols (2.0?g/d) or sunflower oil. There was a three-weeks washout period between the intervention periods.

Results

No significant difference in total- or LDL-cholesterol between the phytosterol and the placebo period were observed after four weeks intervention (0.0?mmol/L (95 % CI: ?0.3 to 0.2), P?=?0.74 and??0.1?mmol/L (95 % CI: ?0.3 to 0.1), P?=?0.32, respectively).

Conclusion

Daily intake of capsules containing 2?g phytosterols did not reduce total- or LDL-cholesterol significantly in a highly relevant target group for the use of phytosterol products. The present results may emphasize the importance of choosing a suitable dosage-delivery system in order to achieve optimal cholesterol lowering effect.

The study was registered at , IDno:.