In a double-blinded, randomized, placebo-controlled crossover study, 41 men and women were randomized into two four-weeks intervention periods with softgel capsules containing either phytosterols (2.0?g/d) or sunflower oil. There was a three-weeks washout period between the intervention periods.
No significant difference in total- or LDL-cholesterol between the phytosterol and the placebo period were observed after four weeks intervention (0.0?mmol/L (95 % CI: ?0.3 to 0.2), P?=?0.74 and??0.1?mmol/L (95 % CI: ?0.3 to 0.1), P?=?0.32, respectively).
Daily intake of capsules containing 2?g phytosterols did not reduce total- or LDL-cholesterol significantly in a highly relevant target group for the use of phytosterol products. The present results may emphasize the importance of choosing a suitable dosage-delivery system in order to achieve optimal cholesterol lowering effect.
The study was registered at , IDno:.