Altered leukocyte distribution under hypercholesterolemia: A cross-sectional study in children with familial hypercholesterolemia

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• 作者：Jacob J. Christensen^a ; ^b ; Liv T. Osnes^c ; Bente Halvorsen^d ; ^e ; ^f ; Kjetil Retterst&oslash ; l^a ; ^b ; Martin P. Bogsrud^g ; Cecilie Wium^b ; Arne Svilaas^b ; Ingunn Narverud^a ; ^g ; Stine M. Ulven^a ; På ; l Aukrust^d ; ^e ; ^f ; ^h ; Kirsten B. Holven^a ; ^g ; ^{k.b.holven@medisin.uio.no}
• 关键词：Familial hypercholesterolemia ; Children ; Inflammation ; Monocytes ; Lymphocytes ; Atherosclerosis
• 刊名：Atherosclerosis
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：256
• 期：Complete
• 页码：67-74
• 全文大小：937 K
• 卷排序：256

文摘

Certain leukocyte subpopulations may be of particular importance in atherosclerosis. By flow cytometry, we analyzed leukocyte subpopulations in familial hypercholesterolemia (FH) and healthy children. FH children with low HDL-C had a shift in the monocyte subpopulations towards a pro-inflammatory phenotype. Monocytes expressing CD18 and serum E-selectin were also higher in FH children with low HDL-C. Our data suggest an activation of monocytes at a very early stage of atherosclerosis in humans.