PCSK9 and lipoprotein (a) levels are two predictors of coronary artery calcification in asymptomatic patients with familial hypercholesterolemia
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- 作者：Rodrigo Alonsoa ; b ; Pedro Mataa ; Ovidio Muñ ; izc ; Francisco Fuentes-Jimenezd ; e ; Jose Luis Dí ; azf ; Daniel Zambó ; ng ; Marta Tomá ; sh ; Cesar Martini ; Thomas Moyonj ; Mikaë ; l Croyalj ; Auré ; lie Thedrezj ; Gilles Lambertj ; k ; l ; m ; gilles.lambert@univ-reunion.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Coronary artery calcification ; Lipids and lipoprotein metabolism ; Hypercholesterolemia
- 刊名：Atherosclerosis
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：254
- 期：Complete
- 页码：249-253
- 全文大小：415 K
文摘
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Factors besides LDL may determine why some patients with familial hypercholesterolemia develop CAD earlier in life than others.
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We correlated coronary artery calcifications with PCSK9 and Lp(a) levels in 161 asymptomatic patients with molecular diagnosis of FH.
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We report that both PCSK9 and Lp(a) are independently predictive of elevated coronary artery calcium scores, an excellent marker of atherosclerotic burden.