Trans-Binding Mechanism of Ubiquitin-like Protein Activation Revealed by a UBA5-UFM1 Complex
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- 作者：Walaa Oweis1 ; Prasanth Padala1 ; Fouad Hassouna1 ; Einav Cohen-Kfir1 ; Dalton R. Gibbs2 ; Emily A. Todd2 ; Christopher E. Berndsen2 ; Reuven Wiener1 ; 3 ; reuvenw@ekmd.huji.ac.il" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：20 September 2016
- 年：2016
- 卷：16
- 期：12
- 页码：3113-3120
- 全文大小：2664 K
文摘
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The crystal structure of the UBA5-UFM1 complex is resolved
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Dimerization of UBA5 is required for UFM1 activation
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Activation of UFM1 by UBA5 is executed through a trans-binding mechanism
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UBA5 transfers UFM1 to UFC1 using a trans mechanism