Dihydropyridines and atypical MDR: A novel perspective of designing general reversal agents for both typical and atypical MDR

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• 作者：Ramin Miri ; Ahmadreza Mehdipour
• 关键词：Dihydropyridines ; Multidrug resistance ; Atypical MDR ; Ca²⁺ channel blocking activity
• 刊名：Bioorganic and Medicinal Chemistry
• 出版年：2008
• 出版时间：15 September 2008
• 年：2008
• 卷：16
• 期：18
• 页码：8329-8334
• 全文大小：195 K

文摘

Multidrug resistance (MDR) is defined as resistance of tumor cells to the cytotoxic action of multiple structurally dissimilar and functionally divergent drugs commonly used in chemotherapy. 1,4-Dihydropyridines (DHP_s) are one of the major classes of Ca²⁺ channel blockers, and it has been shown that these agents are a new class of drug resistance reversers in cancer treatment. Analysis of various investigations on MDR reversing effects of DHPs shows that they can be a potential class for designing compounds simultaneously effective on both typical and atypical MDR. Also, it is possible to include some considerations on essential structural features for MDR reversing and further decreasing of Ca²⁺ channel blocking activity as an adverse effect.