Orexin/hypocretin-1 receptor antagonism reduces ethanol self-administration and reinstatement selectively in highly-motivated rats
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- 作者：David E. Moormana ; b ; 1 ; moorman@cns.umass.edu" class="auth_mail" title="E-mail the corresponding author ; Morgan H. Jamesa ; c ; e ; 1 ; morgan.james@rutgers.edu" class="auth_mail" title="E-mail the corresponding author ; Elisabeth A. Kilroya ; d ; Gary Aston-Jonesa ; c
- 关键词：Alcoholism ; Reward ; Lateral hypothalamus ; Neuropeptide ; Motivation ; Individual differences
- 刊名：Brain Research
- 出版年：2017
- 出版时间：1 January 2017
- 年：2017
- 卷：1654
- 期：part_PA
- 页码：34-42
- 全文大小：470 K
文摘
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Rats were segregated into low (LR) and high (HR) operant responders for 20% ethanol.
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Operant ethanol seeking was not correlated with homecage ethanol drinking.
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Orexin-1 receptor antagonism decreased both self-administration and reinstatement.
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The effects were selective for HR but not LR animals.
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Orexin signaling may underlie elevated motivation in alcohol abuse and addiction.