Role of recombinant human erythropoietin loading chitosan-tripolyphosphate nanoparticles in busulfan-induced genotoxicity: Analysis of DNA fragmentation via comet assay in cultured HepG2 cells
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- 作者：Nasrin Ghassemi-Barghia ; Ngeternal67@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Jaleh Varshosazb ; varshosaz@pharm.mui.ac.ir" class="auth_mail" title="E-mail the corresponding author ; Mahmoud Etebaria ; etebari@pharm.mui.ac.ir" class="auth_mail" title="E-mail the corresponding author ; Abbas Jafarian Dehkordia ; jafarian@pharm.mui.ac.ir" class="auth_mail" title="E-mail the corresponding author
- 关键词：Busulfan ; rhEPO ; ROS ; Nanoparticles ; Comet assay ; Chitosan-tripolyphosphate
- 刊名：Toxicology in Vitro
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：36
- 期：Complete
- 页码：46-52
- 全文大小：727 K
文摘
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Both regular rhEPO and CS-TPP-EPO nanoparticles reduced the busulfan-induced genotoxicity as measured with the comet assay.
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Both regular rhEPO and CS-TPP-EPO nanoparticles decreased busulfan-induced ROS generation.
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Both regular rhEPO and CS-TPP-EPO nanoparticles enhanced intracellular glutathione levels.
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CS-TPP-EPO nanoparticles were more effective than regular rhEPO.