The enantioselective total synthesis of the antitumor macrolide natural product rhizoxin D

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• 作者：Lafontaine ; Jennifer A. ; Provencal ; David P. ; Gardelli ; Cristina ; Leahy ; James W.
• 刊名：Tetrahedron Letters
• 出版年：1999
• 出版时间：May 28, 1999
• 年：1999
• 卷：40
• 期：22
• 页码：4145-4148
• 全文大小：258 K

文摘

A convergent, enantioselective total synthesis of rhizoxin D (didesepoxyrhizoxin), a potent antitumor natural product, was achieved via three critical olefinations, including a Horner-Emmons macrocyclization.