Sema-1a Reverse Signaling Promotes Midline Crossing in Response to Secreted Semaphorins

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• 作者：Melissa Hernandez-Fleming¹ ; Ethan W. Rohrbach¹ ; Greg J. Bashaw¹ ; ² ; ^{gbashaw@mail.med.upenn.edu}
• 关键词：axon guidance ; midline ; semaphorin ; Drosophila ; reverse signaling ; netrin ; dcc ; frazzled ; chemoattraction ; growth cone
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：3 January 2017
• 年：2017
• 卷：18
• 期：1
• 页码：174-184
• 全文大小：3234 K
• 卷排序：18

文摘

Sema-1a functions independently of Netrin to promote midline crossing Sema-1a mediates midline crossing through reverse signaling in commissural neurons RhoGAPp190 and the negative regulation of Rho1 are required for midline crossing The Secreted Sema-2s function as attractive or adhesive midline cues