Leishmania (Viannia) braziliensis amastigotes induces the expression of TNFα and IL-10 by human peripheral blood mononuclear cells in vitro in a TLR4-dependent manner
详细信息 查看全文
- 作者：Hé ; lio Galdino Jr.a ; 1 ; Rodrigo Saar Gomesa ; 1 ; Jessica Cristina dos Santosa ; b ; Lí ; via Lara Pessonia ; Anetí ; cia Eduarda Maldanera ; Sté ; fanne Madalena Marquesa ; Clayson Moura Gomesa ; Miriam Leandro Dortaa ; Milton Adriano Pelli de Oliveiraa ; Leo A.B. Joostena ; b ; leo.joosten@radboudumc.nl" class="auth_mail" title="E-mail the corresponding author ; Fá ; tima Ribeiro-Diasa ; fatimardias@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Leishmania (Viannia) braziliensis ; Amastigotes ; TLR4 ; TNFα ; IL-10 ; Human PBMCs
- 刊名：Cytokine
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：88
- 期：Complete
- 页码：184-192
- 全文大小：1428 K
文摘
- •
L. braziliensis amastigotes induce TNFα and IL-10 in IFNγ-primed PBMCs.
- •
Induction of TNFα and IL-10 by L. braziliensis amastigotes is dependent on TLR4.
- •
TLR4 agonist increased L. braziliensis amastigote-induced TNFα.
- •
L. braziliensis amastigotes decrease TLR4 expression on monocyte surface.