Acephate exposure during a perinatal life program to type 2 diabetes

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• 作者：Tatiane Aparecida Ribeiro^a ; ¹ ; ^{tatianeribeiro2@hotmail.com} ; Kelly Valé ; rio Prates^a ; ¹ ; Audrei Pavanello^a ; Ananda Malta^a ; Laize Peron Tó ; folo^a ; Isabela Peixoto Martins^a ; Jú ; lio Cezar de Oliveira^f ; Rosiane Aparecida Miranda^d ; Rodrigo Mello Gomes^h ; Elaine Vieira^a ; Claudiné ; ia Conationi da Silva Franco^a ; Luiz Felipe Barella^c ; Flá ; vio Andrade Francisco^a ; Vander Silva Alves^a ; Sandra da Silva Silveira^a ; Veridiana Mota Moreira^a ; Gabriel Sergio Fabricio^g ; Kesia Palma-Rigo^a ; Deborah M. Sloboda^b ; Paulo Cezar de Freitas Mathias^a ; ^e
• 关键词：ipGTT ; intraperitoneal glucose tolerance test ; ipITT ; intraperitoneal insulin tolerance test ; ivGTT ; intravenous glucose tolerance test ; ipPTT ; intraperitoneal pyruvate tolerance test ; BuChE ; butyrylcholinesterase ; DOHaD ; developmental origins of health and disease ; OP ; organophosphates ; COBEA ; Brazilian association for animal experimentation ; AChE ; acetylcholinesterase ; Ach ; acetylcholine ; ACE ; acephate ; AUC ; area under the curve ; P0 ; post ; natal day 0 ; P21 ; post-natal day 21 ; P90 ; post-natal d
• 刊名：Toxicology
• 出版年：2016
• 出版时间：30 November 2016
• 年：2016
• 卷：372
• 期：Complete
• 页码：12-21
• 全文大小：1323 K
• 卷排序：372

文摘

Acephate has been used extensively as an insecticide in agriculture. Its downstream sequelae are associated with hyperglycemia, lipid metabolism dysfunction, DNA damage, and cancer, which are rapidly growing epidemics and which lead to increased morbidity and mortality rates and soaring health-care costs. Developing interventions will require a comprehensive understanding of which excess insecticides during perinatal life can cause insulin resistance and type 2 diabetes. A Wistar rat animal model suggests that acephate exposure during pregnancy and lactation causes alterations in maternal glucose metabolism and programs the offspring to be susceptible to type 2 diabetes at adulthood. Therapeutic approaches based on preventive actions to food contaminated with insecticides during pregnancy and lactation could prevent new cases of type 2 diabetes.