Reprint of “Modeling the intracellular replication of influenza A virus in the presence of defective interfering RNAs
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- 作者：Tanja Laskea ; 1 ; Frank Stefan Heldtb ; 1 ; Helene Hoffmannb ; Timo Frensinga ; b ; frensing@mpi-magdeburg.mpg.de" class="auth_mail" title="E-mail the corresponding author ; Udo Reichla ; b
- 关键词：cRNP ; complementary ribonucleoprotein complex ; DI RNA ; defective interfering RNA ; DIP ; defective interfering particle ; FL ; full-length ; HAU ; haemagglutinating units ; hpi ; hours post infection ; MOI ; multiplicity of infection ; NEP ; nuclear export protein ; NP ; nucleoprotein ; nt ; nucleotides ; PFU ; plaque forming units ; RdRp ; RNA-dependent RNA polymerase ; RNP ; ribonucleoprotein complex ; STV ; standard virus ; vRNA ; viral RNA ; vRNP ; viral ribonucleoprotein complex
- 刊名：Virus Research
- 出版年：2016
- 出版时间：15 June 2016
- 年：2016
- 卷：218
- 期：Complete
- 页码：86-95
- 全文大小：1675 K
文摘
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We developed a model for the intracellular replication of influenza virus DI RNAs.
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The model elucidates changes in the release of progeny DIPs and standard virus.
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DI RNA synthesis leads to the depletion of viral proteins (encapsidation factors).
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The replication advantage and co-infection timing affect DI RNA propagation.
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DI RNAs of polymerase gene origin are more competitive than others.