An effective in vitro and in vivo antileishmanial activity and mechanism of action of 8-hydroxyquinoline against Leishmania species causing visceral and tegumentary leishmaniasis
详细信息 查看全文
- 作者：Mariana Costa Duartea ; Letí ; cia Martins dos Reis Lagea ; Daniela Pagliara Lageb ; Juliana Tonini Mesquitac ; Beatriz Cristina Silveira Sallesb ; Stefâ ; nia Neiva Lavoratod ; Daniel Menezes-Souzaa ; Bruno Mendes Roatta ; Ricardo José ; Alvesd ; e ; Carlos Alberto Pereira Tavaresf ; André ; Gustavo Temponec ; Eduardo Antonio Ferraz Coelhob ; eduardoferrazcoelho@yahoo.com.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：Leishmania ; 8-Hydroxyquinoline ; Antileishmanial activity ; Leishmaniasis ; Treatment ; Toxicity
- 刊名：Veterinary Parasitology
- 出版年：2016
- 出版时间：15 February 2016
- 年：2016
- 卷：217
- 期：Complete
- 页码：81-88
- 全文大小：774 K
文摘
- •
New therapeutic strategies to treat leishmaniasis.
- •
8-HQN was tested against promastigotes and amastigotes of three Leishmania species.
- •
It presented better in vitro results in comparison to amphotericin B.
- •
8-HQN causes alterations in the Leishmania mitochondrial membrane potential.
- •
It was able to reduce the lesion diameter and parasite load in BALB/c mice.