Histochemical analysis of collagen fibers in giant cell fibroma and inflammatory fibrous hyperplasia

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• 作者：Mô ; nica Jarema Schmidt^a ; André ; Tschoeke^a ; Lú ; cia Noronha^a ; Rafaela Scariot de Moraes^a ; Ricardo Alves Mesquita^b ; Ana Maria Trindade Gré ; gio^a ; Luciana Reis Azevedo Alanis^a ; Sé ; rgio Aparecido Igná ; cio^a ; Jean Nunes dos Santos^c ; Antonio Adilson Soares de Lima^d ; Teixeira Suelen Luiz^a ; Arielli Carine Michels^a ; Maria Cá ; ssia Ferreira Aguiar^b ; Aline Cristina Batista Rodrigues Johann^a ; ^{alinecristinabatista@yahoo.com.br" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Fibroma ; Picrosirius red ; Collagen
• 刊名：Acta Histochemica
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：118
• 期：5
• 页码：451-455
• 全文大小：1063 K

文摘

The aim was to investigate collagen fibers in giant cell fibroma, inflammatory fibrous hyperplasia, and oral normal mucosa.

Materials and methods

Sixty-six cases were stained with picrosirius red. The slides were observed under polarization, followed by the measurement of the area and the percentage of the type I and type III collagens. The age and gender were obtained from the clinical records.

Results

No differences could be observed in both the area and percentage of the type I and type III collagens within the categories of lesions and normal mucosa. In the giant cells fibroma, a greater area and percentage of type I collagen could be identified in individuals of less than 41.5 years (p < 0.05).

Conclusion

The distribution of type I and type III collagen fibers in the studied lesions followed a similar pattern to that observed in the normal mucosa, indicating a normal collagen maturation process of type III to I. The study supports that multinucleated and stellate cells of the giant cell fibroma appear to be functional within collagen types III and I turnover. The greater amount of type I collagen identified in giant cell fibroma in individuals of less than 41.5 years reinforce the neoplastic nature of lesion.