The FOXO1 Transcription Factor Instructs the Germinal Center Dark Zone Program
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- 作者：David Dominguez-Sola1 ; 6 ; 7 ; 8 ; david.dominguez-sola@mssm.edu" class="auth_mail" title="E-mail the corresponding author ; Jennifer Kung6 ; Antony B. Holmes1 ; Victoria A. Wells1 ; Tongwei Mo1 ; Katia Basso1 ; 2 ; Riccardo Dalla-Favera1 ; 2 ; 3 ; 4 ; 5 ; rd10@cumc.columbia.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Immunity
- 出版年：2015
- 出版时间：15 December 2015
- 年：2015
- 卷：43
- 期：6
- 页码：1064-1074
- 全文大小：3533 K
文摘
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FOXO1 expression in the germinal center is restricted to dark zone B cells
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FOXO1-null mouse germinal centers lack dark zones and lose architectural polarity
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FOXO1 deletion impairs affinity maturation and IgG1 class switch recombination
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FOXO1 instructs the dark zone gene program directly and by licensing BCL6 activity