Low-dose estrogen and drospirenone combination: effects on glycoinsulinemic metabolism and other cardiovascular risk factors in healthy postmenopausal women

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• 作者：Paola Villa ; Rosanna Suriano ; Luigi Ricciardi ; Valeria Tagliaferri ; Simona De Cicco ; Pasquale De Franciscis ; Nicola Colacurci ; Antonio Lanzone
• 关键词：Drospirenone ; insulin metabolism ; menopause ; cardiovascular disease
• 刊名：Fertility and Sterility
• 出版年：2011
• 出版时间：January 2011
• 年：2011
• 卷：95
• 期：1
• 页码：158-163
• 全文大小：255 K

文摘

Objective

To evaluate the effects of a daily E₂ (1 mg) plus drospirenone oral formulation (2 mg) on glycoinsulinemic metabolism, lipid profile, and endothelial function in symptomatic healthy menopausal women.

Design

Randomized, double-blind study.

Setting

Operative Division of Endocrinological Gynecology, Catholic University of the Sacred Heart, Rome, Italy.

Patient(s)

Forty postmenopausal women.

Intervention(s)

Patients were randomly submitted to receive treatment with an oral dose of E₂ (1 mg) plus drospirenone (2 mg) (group A) or placebo (group B).

Main Outcome Measure(s)

Hormonal and lipid assessment; evaluation of glucose and insulin metabolism by the clamp test and the oral glucose tolerance test; evaluation of endothelial function by the vascular reactivity test.

Result(s)

Total cholesterol levels, low-density lipoprotein cholesterol levels, and nonesterified fatty acids levels significantly decreased both after 3 and 6 months. No changes in high-density lipoprotein, triglycerides, apolipoprotein A1, apolipoprotein B, and lipoprotein (a) were found. Treatment resulted in few changes in glycoinsulinemic metabolism. We observed a significant reduction of the area under curve of insulin after 6 months of therapy. Endothelial function was significantly influenced by treatment, and an improvement in both flow-mediated dilatation and nitrate-mediated dilatation values after 6 months was observed.

Conclusion(s)

Low-dose E₂/drospirenone treatment did not reveal any negative effect on carbohydrate metabolism, acting in a neutral way on insulin sensitivity. The treatment induced favorable changes in lipid profile and showed a significant improvement of vascular reactivity.