Bioengineered FSTL1 Patches Restore Cardiac Function Following Myocardial Infarction

详细信息    查看全文

• 作者：Ann-Kristin Altekö ; ester¹ ; Richard P. Harvey¹ ; ^{r.harvey@victorchang.edu.au" class="auth_mail" title="E-mail the corresponding author}
• 刊名：Trends in Molecular Medicine
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：21
• 期：12
• 页码：731-733
• 全文大小：835 K

文摘

Improving the limited ability of the heart to regenerate after infarction is crucial. Researchers now demonstrate that delivery of follistatin-like 1 (FSTL1) into injured hearts via collagen patches stimulates cardiomyocyte proliferation and cardiac functional recovery. These findings highlight the epicardium as a source of novel regenerative factors and biomimetic nanomaterials in cardiac translational medicine.