- 作者：Mario Sé ; né ; chal ; Isabelle Lemieux ; Isabel Beucler ; Gerard Drobinski ; Sylvie Cormont ; Michelle Dubois ; Iradj Gandjbakhch ; Jean-Pierre Despré ; s and Richard Dorent
- 刊名：The Journal of Heart and Lung Transplantation
- 出版年：2005
- 出版时间：2005
- 年：2005
- 卷：24
- 期：7
- 页码：819-826
- 全文大小：209 K
Background
This study evaluated the prevalence of the atherogenic metabolic triad and the hypothesis that waist circumference and fasting triglyceride concentrations could be used as screening tools for identification of the atherogenic metabolic triad in a population of heart transplant men. It also evaluated the relationship between the atherogenic metabolic triad and coronary artery disease (CAD).Methods
In the study group of 83 consecutive male heart transplant patients having their routine annual coronarography, 23 patients (28 % ) were characterized by the atherogenic metabolic triad defined by the presence of elevated fasting insulin and apolipoprotein B concentrations and by small low-density lipoprotein (LDL) particles.
Results
Seventy-seven per cent of patients with waist circumference values ≥ 90 cm and with elevated triglyceride levels (≥2.0 mmol/liter) were characterized by this atherogenic metabolic triad. Patients with the atherogenic metabolic triad were at markedly increased risk of CAD (odds ratio of 25.3, 95 % CI: 1.11–577.3, p < 0.04) compared to heart transplant patients without the atherogenic metabolic triad.
Conclusions
About 30 % of heart transplant patients showed the features of the atherogenic metabolic triad. Measurement and interpretation of waist circumference and fasting triglycerides could be used among heart transplant patients to early identify men characterized by the presence of elevated fasting insulin and apolipoprotein B concentrations and small LDL particles. The presence of the atherogenic metabolic triad identified patients at high risk of CAD even in the heart transplant population.