Everolimus in de novo cardiac transplantation: pharmacokinetics, therapeutic range, and influence on cyclosporine exposure

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• 作者：Kovarik ; John M. ; Eisen ; Howard ; Dorent ; Richard ; Mancini ; Donna ; Vigano ; Mario ; Rouilly ; Marisel ; et. al.
• 刊名：The Journal of Heart and Lung Transplantation
• 出版年：2003
• 出版时间：October, 2003
• 年：2003
• 卷：22
• 期：10
• 页码：1117-1125
• 全文大小：132 K

文摘

We evaluated exposure, safety, and efficacy data from an international Phase 3 trial of everolimus in de novo heart transplantation to characterize the longitudinal pharmacokinetics of everolimus and cyclosporine and to identify a therapeutic concentration range for everolimus.