Francisella tularensis Live Vaccine Strain deficient in capB and overexpressing the fusion protein of IglA, IglB, and IglC from the bfr promoter induces improved protection against F. tularensis respiratory challenge
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- 作者：Qingmei Jiaa ; QJia@mednet.ucla.edu" class="auth_mail" title="E-mail the corresponding author ; Richard Bowenb ; rbowen@rams.colostate.edu" class="auth_mail" title="E-mail the corresponding author ; Bai-Yu Leea ; BaLee@mednet.ucla.edu" class="auth_mail" title="E-mail the corresponding author ; Barbara Jane Dillona ; BDillon@mednet.ucla.edu" class="auth_mail" title="E-mail the corresponding author ; Sa&scaron ; a Masle&scaron ; a-Galića ; SGalic@mednet.ucla.edu" class="auth_mail" title="E-mail the corresponding author ; Marcus A. Horwitza ; MHorwitz@mednet.ucla.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Francisella tularensis ; Vaccine ; LVS ΔcapB ; Francisella pathogenicity island ; Type VI secretion system ; Bioterrorism
- 刊名：Vaccine
- 出版年：2016
- 出版时间：22 September 2016
- 年：2016
- 卷：34
- 期：41
- 页码：4969-4978
- 全文大小：2742 K
文摘
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LVS ΔcapB express high amounts of FPI proteins from bacterioferritin (bfr) promoter.
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rLVS ΔcapB express more IglA, B, C or ABC than parental LVS ΔcapB and are stable.
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rLVS ΔcapB/bfr-iglC or bfr-iglABC induce greater T-cell immunity than LVS ΔcapB.
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rLVS ΔcapB/bfr-iglABC i.d. provides better protection against Schu S4 than LVS ΔcapB.
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rLVS ΔcapB/bfr-iglABC provides partial immediate pre- and post-exposure prophylaxis.