Zolpidem does not serve as reinforcer in humans subjected to simulated shift work

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• 作者：Matthew G. Kirkpatrick ; Margaret Haney ; Suzanne K. Vosburg ; S ; ra D. Comer ; Richard W. Foltin ; Carl L. Hart
• 关键词：Zolpidem self-administration ; Performance ; Subjective-effects ; Sleep ; Shift work ; Humans
• 刊名：Drug and Alcohol Dependence
• 出版年：2010
• 出版时间：1 November 2010
• 年：2010
• 卷：112
• 期：1-2
• 页码：168-171
• 全文大小：158 K

文摘

Zolpidem attenuates shift-change-related sleep and performance disruptions. It is unknown whether these benefits alter the reinforcing effects of the drug during shift work. This study examined zolpidem-related reinforcing effects during simulated shift work. Eleven volunteers (3F, 8M) completed this 16-day within-participant, residential laboratory study. Each day participants were given an opportunity to self-administer oral zolpidem (10 mg) or receive a $1 voucher immediately following a 9-h work period and immediately before going to bed. Participants worked under two shift conditions: (1) during the night shift, participants completed computerized task batteries from 00:30 to 09:30 h and went to bed at 16:00 h and (2) during the day shift, participants completed task batteries from 08:30 to 17:30 h and went to bed at 24:00 h. Shift conditions alternated three times during the study. Despite the fact that sleep, psychomotor performance, and some ratings of mood were disrupted during night-shift work, there was no significant effect of shift on choice to take zolpidem. Overall, participants selected markedly fewer zolpidem doses than monetary vouchers (17 % versus 83 % ). Thus, zolpidem did not serve as a reinforcer even when sleep was disrupted. These data are consistent with previous reports indicating that sedatives produce limited reinforcing effects in individuals without a history of drug abuse.