Using a novel alternative to drug choice in a human laboratory model of a cocaine binge: A game of chance

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• 作者：Suzanne K. Vosburg ; Margaret Haney ; Eric Rubin ; Richard W. Foltin
• 关键词：Self-administration ; Cocaine ; Binge ; Behavior
• 刊名：Drug and Alcohol Dependence
• 出版年：2010
• 出版时间：1 July 2010
• 年：2010
• 卷：110
• 期：1-2
• 页码：144-150
• 全文大小：754 K

文摘

Human laboratory studies have shown that, once initiated, cocaine self-administration is difficult to disrupt using non-drug alternatives. This inpatient study examined whether binge self-administration of cocaine could be altered by an immediate, non-drug reinforcer. Ten cocaine-dependent participants completed 5 consecutive laboratory session days with 2 sessions per day (a model binge), 9 days where cocaine was not available, and subsequent 2 laboratory session days where cocaine was again available (a second model binge). In each laboratory session, participants could choose to either self-administer smoked cocaine or play a game of chance by drawing a pre-determined number of balls from a bingo wheel. Balls were worth monetary amounts from $0 to $20. Participants’ choice to smoke cocaine varied as a function of number of balls drawn. Thus, this game of chance served as an alternative reinforcer to smoking cocaine. Choice varied lawfully as a function of the number of opportunities to earn money indicating that an immediate behavioral alternative can reduce cocaine self-administration after initiation of use. The current model could be used to evaluate whether behavioral and pharmacological manipulations shift choice from cocaine to a non-drug alternative.