Modafinil decreases cocaine choice in human cocaine smokers only when the response requirement and the alternative reinforcer magnitude are large

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• 作者：Richard W. Foltin ; ^{rwf2@cumc.columbia.edu} ; Margaret Haney ; Gillinder Bedi ; & Suzette M. Evans
• 关键词：Cocaine ; Self-administration ; Modafinil ; Drug choice ; Human
• 刊名：Pharmacology Biochemistry and Behavior
• 出版年：2016
• 出版时间：November-December 2016
• 年：2016
• 卷：150-151
• 期：Complete
• 页码：8-13
• 全文大小：321 K
• 卷排序：150

文摘

Increasing the response requirement for cocaine and value of an alternative reinforcer decreased cocaine choice Providing a dose of cocaine without a response requirement did not alter cocaine choice Modafinil decreased cocaine choice only when the response cost for cocaine and value of an alternative reinforcer was high Modafinil should be combined with therapy emphasizing the large personal costs of using cocaine