文摘
Carbaryl exposure may increase solar radiation deleterious effects on melanocytes. Carbaryl, but not solar radiation, induced an oxidative stress response. Carbaryl treatment upregulated the antioxidant gene HMOX1 and inhibited MITF. Combined treatment group induced synergistic DNA damage and cell cycle alteration. Data suggests carbaryl genotoxicity to melanocytes when associated with solar UV.