Reduced-Intensity Allografting as First Transplantation Approach in Relapsed/Refractory Grades One and Two Follicular Lymphoma Provides Improved Outcomes in Long-Term Survivors
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- 作者：Evgeny Klyuchnikov1 ; Ulrike Bacher2 ; Nicolaus M. Krö ; ger1 ; Parameswaran N. Hari3 ; Kwang Woo Ahn3 ; 4 ; Jeanette Carreras3 ; Veronika Bachanova5 ; Asad Bashey6 ; Jonathon B. Cohen7 ; Anita D'Souza3 ; Cé ; sar O. Freytes8 ; Robert Peter Gale9 ; Siddhartha Ganguly10 ; Mark S. Hertzberg11 ; Leona A. Holmberg12 ; Mohamed A. Kharfan-Dabaja13 ; Andreas Klein14 ; Grace H. Ku15 ; Ginna G. Laport16 ; Hillard M. Lazarus17 ; Alan M. Miller18 ; Alberto Mussetti19 ; 20 ; Richard F. Olsson21 ; 22 ; Shimon Slavin23 ; Saad Z. Usmani24 ; Ravi Vij25 ; William A. Wood26 ; David G. Maloney12 ; Anna M. Sureda27 ; 28 ; Sonali M. Smith29 ; Mehdi Hamadani3 ; mhamadani@mcw.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Grade 1 and 2 follicular lymphoma ; Reduced-intensity allogeneic hematopoietic cell transplantation ; Autologous hematopoietic cell transplantation ; Long-time survival
- 刊名：Biology of Blood and Marrow Transplantation
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：21
- 期：12
- 页码：2091-2099
- 全文大小：395 K
文摘
- 1.
We conducted the largest study comparing autologous hematopoietic cell transplantation with allogeneic hematopoietic cell transplantation in grades 1 and 2 follicular lymphoma in rituximab era.
- 2.
In follicular lymphoma patients surviving 2 years after hematopoietic cell transplantation, allografting provided an overall survival benefit.
- 3.
Rituximab resistance does not predict hematopoietic cell transplantation outcomes.
- 4.
Overall survival was better in those with hematopoietic cell transplantation performed from 2008 onward.
- 5.
Second hematological malignancies develop only after a autologous hematopoietic cell transplantation.