M4 Muscarinic Receptor Signaling Ameliorates Striatal Plasticity Deficits in Models of L-DOPA-Induced Dyskinesia
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- 作者：Weixing Shen1 ; Joshua L. Plotkin1 ; Veronica Francardo2 ; Wai Kin D. Ko3 ; 4 ; 5 ; Zhong Xie1 ; Qin Li5 ; Tim Fieblinger2 ; Jü ; rgen Wess6 ; Richard R. Neubig7 ; Craig W. Lindsley8 ; P. Jeffrey Conn8 ; Paul Greengard9 ; Erwan Bezard3 ; 4 ; 5 ; M. Angela Cenci2 ; D. James Surmeier1 ; j-surmeier@northwestern.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Neuron
- 出版年：2015
- 出版时间：18 November 2015
- 年：2015
- 卷：88
- 期：4
- 页码：762-773
- 全文大小：2950 K
文摘
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Activation of M4R signaling promotes LTD by suppressing RGS4 signaling in dSPNs
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M4R signaling blocks LTP induction and enables depotentiation in dSPNs
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In a mouse LID model, M4R signaling blunts abnormal LTP
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In mouse and primate models, systemic treatment with M4R PAMs alleviates LID