Sex hormone measurements using mass spectrometry and sensitive extraction radioimmunoassay and risk of estrogen receptor negative and positive breast cancer: Case control study in UK Collaborative Cancer Trial of Ovarian Cancer Screening (UKCTOCS)
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- 作者：Evangelia-Ourania Fourkalaa ; 1 ; rania4kala@yahoo.co.uk" class="auth_mail" title="E-mail the corresponding author ; Oleg Blyussa ; 1 ; o.blyuss@ucl.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Helen Fieldc ; Helen.Field@leedsth.nhs.uk" class="auth_mail" title="E-mail the corresponding author ; Richard Gunua ; rmjorgg@ucl.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Andy Ryana ; a.ryan@ucl.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Julian Barthc ; Julian.Barth@leedsth.nhs.uk" class="auth_mail" title="E-mail the corresponding author ; Ian Jacobsd ; ian.jacobs@manchester.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Alexey Zaikinb ; alexey.zaikin@ucl.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Anne Dawnaye ; anne.dawnay@uclh.nhs.uk" class="auth_mail" title="E-mail the corresponding author ; Usha Menona ; u.menon@ucl.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：Breast cancer risk ; Estrogen-receptor positive and negative ; Sex steroid hormones
- 刊名：Steroids
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：110
- 期：Complete
- 页码：62-69
- 全文大小：310 K
文摘
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Estradiol and free estradiol were significantly higher prior to diagnosis of ER-negative breast cancer compared with controls.
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Estradiol, free estradiol, free testosterone and SHBG were significantly higher before ER-positive breast cancer diagnosis compared with controls.
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Women had a twofold increased ER-negative breast cancer risk if estradiol and free estradiol were in the top quintile but not androgens or SHBG.
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These associations remained significant only when samples closer to diagnosis were analyzed rather than farer.