Biochemistry to the Rescue: A ClC-2 Auxiliary Subunit Provides a Tangible Link to Leukodystrophy

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• 作者：Merritt  ; C. Maduke¹ ; ^{maduke@stanford.edu} ; Richard  ; J. Reimer²
• 刊名：Neuron
• 出版年：2012
• 出版时间：8 March, 2012
• 年：2012
• 卷：73
• 期：5
• 页码：855-857
• 全文大小：172 K

文摘

ClC-2 is a broadly distributed chloride channel with an enigmatic neurophysiological function. In this issue of Neuron, use a biochemical approach to identify GlialCAM, a protein with a defined link to leukodystrophy, as a ClC-2 auxiliary subunit.