SLC17: A functionally diverse family of organic anion transporters

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• 作者：Richard J. Reimer ^{rjreimer@stanford.edu}
• 关键词：SLC17 ; Type I phosphate transporter ; Vesicular glutamate transporter ; Sialin ; Neurotransmitter transporter ; Vesicular nucleotide transporter ; Organic anion transport
• 刊名：Molecular Aspects of Medicine
• 出版年：2013
• 出版时间：April-June, 2013
• 年：2013
• 卷：34
• 期：2-3
• 页码：350-359
• 全文大小：811 K

文摘

Molecular studies have determined that the SLC17 transporters, a family of nine proteins initially implicated in phosphate transport, mediate the transport of organic anions. While their role in phosphate transport remains uncertain, it is now clear that the transport of organic anions facilitated by this family of proteins is involved in diverse processes ranging from the vesicular storage of the neurotransmitters, to urate metabolism, to the degradation and metabolism of glycoproteins.