Cytological, microbiological and therapeutic aspects of systemic infection in a dog caused by the fungus Phialosimplex caninus

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• 作者：Lynne Sigler ; Beth Hanselman ; Kristiina Ruotsalo ; George Kar Tsui ; Susan Richardson
• 关键词：Phialosimplex caninus ; Canine ; ITS sequencing ; Lymphadenopathy ; Mycosis ; Splenomegaly
• 刊名：Medical Mycology Case Reports
• 出版年：2013
• 年：2013
• 卷：2
• 期：Complete
• 页码：32-36
• 全文大小：1687 K

文摘

A seven-year-old immunocompetent dog presenting with lymphadenopathy, mesenteric masses and splenic nodules was diagnosed with Phialosimplex caninus infection. Cytology of a mesenteric mass aspirate demonstrated few intact cells but numerous variably sized fungal cells and rare hyphal fragments. The identity of the cultured fungus was confirmed by DNA sequencing. Itraconazole therapy improved clinical signs, but the fungus was reisolated at follow-up. P. caninus systemic infection should be suspected in dogs presenting with lymphadenopathy and splenomegaly.