Quantitative profiling of the in vivo enzymatic activity of ricin reveals disparate depurination of different pulmonary cell types
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- 作者：Reut Falach ; Anita Sapoznikov ; Yoav Gal ; Ofir Israeli ; Moshe Leitner ; Nehama Seliger ; Sharon Ehrlich ; Chanoch Kronman ; chanochk@iibr.gov.il" class="auth_mail" title="E-mail the corresponding author ; Tamar Sabo
- 关键词：RTA ; ricin toxin A chain ; RTB ; ricin toxin B chain ; RT ; reverse transcriptase ; BALF ; brobchoalveolar lavage fluid ; PBS ; phosphate buffered saline ; AUC ; area under the curve
- 刊名：Toxicology Letters
- 出版年：2016
- 出版时间：6 September 2016
- 年：2016
- 卷：258
- 期：Complete
- 页码：11-19
- 全文大小：1348 K
文摘
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Maximum depurination in lungs of mice exposed to ricin, is reached at 48 h post exposure.
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The extent of ricin-induced depurination in different cells populating the lungs, varies greatly.
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Anti-ricin antibody treatment, rapidly halts further depurination in the cells of the lung.
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The magnitude of depurination induced by abrin is significantly lower than that of ricin.