Dose-dependent DNA adduct formation by cinnamaldehyde and other food-borne α,β-unsaturated aldehydes predicted by physiologically based in silico modelling
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- 作者：R. Kiwamoto ; reikokiwamoto@hotmail.co.jp" class="auth_mail" title="E-mail the corresponding author ; D. Ploeg ; I.M.C.M. Rietjens ; A. Punt
- 关键词：α ; β-Unsaturated aldehydes ; Cinnamaldehyde ; DNA adducts ; Physiologically based kinetic/dynamic modelling ; Read-across ; Genotoxicity
- 刊名：Toxicology in Vitro
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：31
- 期：Complete
- 页码：114-125
- 全文大小：1151 K
文摘
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Cinnamaldehyde PBK/D models for DNA adduct formation were developed for comparison to other 18 food-borne aldehydes.
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Six out of the 18 aldehydes form less DNA adducts than cinnamaldehyde suggesting negative genotoxicity in vivo.
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At daily intake levels DNA adduct formation by the 18 aldehydes was predicted to be comparable to or lower than that by cinnamaldehyde.
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Proof of principle was provided for the use of PBK/D modelling to facilitate read-across.