Phenomenology of polymorphism: The topological pressure-temperature phase relationships of the dimorphism of finasteride

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• 作者：In¨¨s Gana ; Ren¨¦ C¨¦olin ; Ivo B. Rietveld
• 关键词：Thermodynamics ; API ; Phase behavior ; Dimorphism ; Solid state ; Phase diagram
• 刊名：Thermochimica Acta
• 出版年：2012
• 出版时间：20 October, 2012
• 年：2012
• 卷：546
• 期：Complete
• 页码：134-137
• 全文大小：291 K

文摘

Knowledge of the phase behavior in the solid state of active pharmaceutical ingredients is important for the development of stable drug formulations. The topological method for the construction of pressure-temperature phase diagrams has been applied to study the phase behavior of finasteride. It is demonstrated that with basic calorimetric measurements and X-ray diffraction sufficient data can be obtained to construct a complete topological pressure-temperature phase diagram. The dimorphism observed for finasteride gives rise to a phase diagram similar to the paradigmatic diagram of sulfur. The solid-solid phase relationship is enantiotropic at ordinary pressure and becomes monotropic at elevated pressure, where solid I is the only stable phase.