Immobilization of serum albumin and peptide aptamer for EPC on polydopamine coated titanium surface for enhanced in-situ self-endothelialization
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- 作者：Zhuoyue Chena ; b ; 362947953@qq.com" class="auth_mail" title="E-mail the corresponding author ; Quanli Lic ; Jialong Chena ; c ; Rifang Luoa ; Manfred F. Maitza ; d ; Nan Huanga ; huangnan1956@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Peptide aptamer ; Bovine serum albumin ; Surface modification ; Titanium ; In-situ self-endothelialization
- 刊名：Materials Science & Engineering C
- 出版年：2016
- 出版时间：1 March 2016
- 年：2016
- 卷：60
- 期：Complete
- 页码：219-229
- 全文大小：2965 K
文摘
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We construct a multifunctional surface based on immobilization of BSA and aptamer.
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It can significantly reduce platelet adhesion and fibrinogen adsorption/activation.
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Such functional surface could remarkably enhance EPC adhesion in vitro.
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It can induce rapid self-endothelialization of the implant surface in situ in vivo.
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It is possible to use such a multifunctional surface in cardiovascular implants.