Kamishoyosan reduces conditioned fear-induced freezing behavior in socially isolated ovariectomized rats

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• 作者：Nobuaki Egashira^a ; ^b ; ^{n-egashi@pharm.med.kyushu-u.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Hikari Iba^a ; Haruna Kuwano^a ; Rikako Kawanaka^a ; Masaki Nagao^a ; Hiroshi Moriyama^a ; Takuya Watanabe^a ; Kaori Kubota^a ; ^c ; Shutaro Katsurabayashi^a ; Katsunori Iwasaki^a ; ^c
• 关键词：Kamishoyosan ; Conditioned fear stress ; Ovariectomized rats
• 刊名：Journal of Pharmacological Sciences
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：131
• 期：4
• 页码：279-283
• 全文大小：690 K

文摘

In the present study, we investigated the effect of kamishoyosan (KSS) on conditioned fear-induced freezing in ovariectomized (OVX) rats. Socially isolated OVX rats showed the longest freezing time among the following four groups: group-housed sham-operated (Sham), isolated Sham, group-housed OVX, and isolated OVX rats. Repeated oral administration of KSS (30–300 mg/kg) reduced conditioned fear-induced freezing in socially isolated OVX rats. The reduction of freezing by KSS was reversed by flumazenil (3 mg/kg) and bicuculline (3 mg/kg). These findings suggest that the GABA_A-benzodiazepine receptor complex is involved in the anxiolytic effect of KSS in socially isolated OVX rats.