Encapsulation of cannabinoid drugs in nanostructured lipid carriers

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• 作者：Elisabetta Esposito^a ; Markus Drechsler^b ; Rita Cortesi^a ; Claudio Nastruzzi^a ; ^{nas@unife.it" class="auth_mail" title="E-mail the corresponding author}
• 关键词：NLC ; nanostructured lipid carriers ; CD ; cannabinoid drugs ; RMN ; rimonabant ; cryo-TEM ; cryogenic transmission electron microscopy ; PCS ; photon correlation spectroscopy ; OP ; oil phase ; WP ; water phase
• 刊名：European Journal of Pharmaceutics and Biopharmaceutics
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：102
• 期：Complete
• 页码：87-91
• 全文大小：1185 K

文摘

This study describes the development and optimization of a method to encapsulate the potent and expensive cannabinoids drugs in nanostructured lipid carriers; namely, URB597, AM251 and rimonabant have been considered. NLC production by melt and ultrasonication protocol has been specifically designed to optimize nanoparticle recovery and drug encapsulation efficiency. Special care has been devoted to the modality of oil and water phase emulsification and the entire production has been studied and discussed. NLC recovery, morphology, dimensional distribution and encapsulation efficiency are presented.