Enhanced discriminative stimulus effects of Δ9-THC in the presence of cannabidiol and 8-OH-DPAT in rhesus monkeys
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- 作者：Lance R. McMahon mcmahonl@uthscsa.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cannabinoid ; Rhesus monkey ; Drug discrimination ; Cannabidiol ; 8-OH-DPAT ; Serotonin ; 5-HT1A ; Rimonabant ; Dependence
- 刊名：Drug and Alcohol Dependence
- 出版年：2016
- 出版时间：1 August 2016
- 年：2016
- 卷：165
- 期：Complete
- 页码：87-93
- 全文大小：477 K
文摘
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Cannabidiol lacks CB1 receptor agonist or antagonist activity in primates.
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Cannabidiol amounts larger than those in Cannabis or nabiximols enhance Δ9-THC.
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Cannabidiol and a 5-HT1A receptor agonist have overlapping behavioral effects.
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5-HT1A agonism enhances the CB1 receptor-mediated effects of Δ9-THC.