sGC stimulators: Evidence for riociguat beyond groups 1 and 4 pulmonary hypertension

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• 作者：Raymond Benza^a ; ^{Raymond.BENZA@ahn.org} ; Stephen Mathai^b ; Steven D. Nathan^c
• 关键词：NO-sGC-cGMP pathway ; Riociguat ; Pulmonary arterial hypertension ; sGC stimulators
• 刊名：Respiratory Medicine
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：122
• 期：supp_S1
• 页码：S28-S34
• 全文大小：536 K
• 卷排序：122

文摘

Riociguat stimulates sGC independently of NO, increasing production of cGMP. Riociguat improved hemodynamics w/out interfering with gas exchange in PH-ILD. Riociguat's antifibrotic properties may be beneficial in PH-sLVD.