Epidemiological study of multiple sclerosis in La Rioja

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• 作者：M. B&aacute ; rtulos Iglesias^a ; ^b ; ^{mbartulosiglesias@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; M.E. Marzo Sola^c ; L.A. Estrella Ruiz^d ; ^e ; Y. Bravo Anguiano^b
• 关键词：Prevalence ; Epidemiology ; Multiple sclerosis ; Spain ; Incidence ; La Rioja
• 刊名：Neurología (English Edition)
• 出版年：2015
• 出版时间：November-December 2015
• 年：2015
• 卷：30
• 期：9
• 页码：552-560
• 全文大小：742 K

文摘

Multiple sclerosis is a demyelinating disease that causes severe disability in younger patients. Many epidemiology studies have confirmed a variable prevalence. The objective of this study was to analyse the prevalence of this disease in La Rioja (Spain), using such variables as age and sex; type of progression, initial form of the disease, EDSS and number of relapses; disease-modifying treatment and reasons for treatment withdrawal; personal and family history of cancer; and incidence and mortality.

ec_2">Methods

Analysis of patients in La Rioja diagnosed with MS (according to Poser criteria or the 2005 McDonald criteria) during a 10-year period (2001-2011). Data were collected from hospital records, multiple sclerosis associations, and personal records kept by neurologists.

ec_3">Results

The MS prevalence rate in La Rioja is 65 patients/100 000 inhabitants with an incidence rate of 3.5 cases/100 000 residents per year. Relapsing-remitting MS is present in 67.6% of the patient total. Mean age of onset is 20-29 years (range 12-70). Most EDSS scores were mostly ≤2. Untreated MS cases account for 47.6% of the total, and the most commonly used therapy is interferon. We detected four haematological tumours and seven families with multiple members affected by MS.

ec_4">Conclusions

Prevalence and incidence are similar to those found in other regions of Spain. The average age at onset age for primary progressive MS is slightly higher than in other papers (40-49 years). In families with multiple patients, MS may be more aggressive. Disability in these patients remains very severe. We require more epidemiology studies with a variety of data gathering methods to support findings for prevalence obtained in different provinces.