Thermogravimetric analysis coupled with chemometrics as a powerful predictive tool for ß-thalassemia screening
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- 作者：Roberta Risolutia ; roberta.risoluti@uniroma1.it" class="auth_mail" title="E-mail the corresponding author ; Stefano Materazzia ; Francesco Sorrentinob ; Laura Maffeib ; Patrizia Capraric
- 关键词：TGA ; thermogravimetric analysis ; PCA ; Principal Component Analysis ; PLS-DA ; Partial Least Square Discriminant Analysis ; Hb ; hemoglobin ; MCV ; mean corpuscular volume ; MCH ; mean corpuscular hemoglobin ; HbF ; fetal hemoglobin ; TG ; thermogravimetry ; DTG ; derivative thermogravimetric curve ; PC ; Principal Component ; RBC ; red blood cell ; Hct ; hematocrit ; RDW ; red cell distribution width
- 刊名：Talanta
- 出版年：2016
- 出版时间：1 October 2016
- 年：2016
- 卷：159
- 期：Complete
- 页码：425-432
- 全文大小：1414 K
文摘
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The coupling of TGA and Chemometrics is proposed as an innovative approach in blood analysis.
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TGA/Chemometrics predicts ß-thalassemia using few microliters of blood with no pretreatment.
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A model for β-thalassemia classification has been validated.
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A cost-effective tool for β-thalassemia screening in patients with heterogeneous clinical severity.