Celecoxib and omega-3 fatty acids alone and in combination with risperidone affect the behavior and brain biochemistry in amphetamine-induced model of schizophrenia

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• 作者：Alaa El-Sayed El-Sisi^a ; Samia Salem Sokkar^a ; Magda El-Sayed El-Sayad^a ; Ehab Sayed Ramadan^b ; Enass Yossef Osman^a ; ^{enassyoussefosman@yahoo.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：MDA ; malondialdeyde ; TNF-α ; tumor necrosis factor alpha ; DA ; dopamine ; 5-HT ; serotonin ; NO ; nitric oxide ; IL-6 ; interleukin-6 ; COX-2 ; cyclooxygenase-2 ; PGs ; prostaglandins ; FA ; fatty acids ; AMPH ; amphetamine ; RIS ; risperidone ; CELECO ; celecoxib ; OMEG-3 ; omega-3 fatty acids
• 刊名：Biomedicine & Pharmacotherapy
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：82
• 期：Complete
• 页码：425-431
• 全文大小：867 K

文摘

The implications of oxidative stress and neuro-inflammation in the pathogenesis of schizophrenia have been elucidated. Despite their effectiveness against positive symptoms of schizophrenia, antipsychotics have limited effectiveness against negative and cognitive symptoms and are associated with remarkable adverse effects. The use of celecoxib or omega-3 in schizophrenia may have beneficial effects. This study aimed to evaluate the possible efficacies of celecoxib, omega-3 or the combination of celecoxib + risperidone and omega-3+ risperidone compared to risperidone on the behavior and brain biochemistry in rats. In the present study, an amphetamine-induced model of schizophrenia in adult male rats was used to evaluate the effects of celecoxib, omega-3, celecoxib + risperidone and omega-3+ risperidone on the behavior of animals and on brain lipid peroxidation or tumor necrosis factor-alpha. In the water maze task, celecoxib, omega-3, celecoxib + risperidone, omega-3+ risperidone significantly decreased the latency time compared to amphetamine-treated group. Celecoxib, omega-3, celecoxib + risperidone, omega–3 + risperidone also significantly reversed the decreased spontaneous alternation induced by amphetamine in the Y-maze task. In the social interaction task, groups treated with celecoxib, omega-3, celecoxib + risperidone, omega-3+ risperidone spent less time to recognize foreign animals than animals in the amphetamine-treated group. Increased brain MDA and TNF-α levels due to amphetamine were significantly reduced in groups treated with celecoxib + risperidone or omega-3+ risperidone. The present findings showed that celecoxib or omega-3 can attenuate amphetamine- induced behavioral impairment and these effects may be associated with their ability to decrease lipid peroxidation and cytokine release. Celecoxib or omega-3 may be promising candidates as adjuvant therapy for schizophrenia.