Time evolution of noise induced oxidation in outer hair cells: Role of NAD(P)H and plasma membrane fluidity
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- 作者：Giuseppe Mauluccia ; Diana Troianib ; d.troiani@rm.unicatt.it" class="auth_mail ; Sara Letizia Maria Eramob ; Fabiola Pacielloc ; Maria Vittoria Poddab ; Gaetano Paludettic ; Massimiliano Papia ; Alessandro Maioranaa ; Valentina Palmieria ; Marco De Spiritoa ; Anna Rita Fetonic
- 关键词：(NAD(P)H) ; Nicotinamide adenine dinucleotide phosphate ; (ROS) ; Reactive oxygen species ; (OHCs) ; outer hair cells ; (MET) ; mechanoelectrical transduction ; (LW) ; lateral wall ; (ABR) ; auditory brainstem response ; (4-HNE) ; 4-hydroxy-2-nonenal ; (BSA) ; bovine serum albumin ; (DMEM) ; Dulbecco's Modified Eagle's Medium ; (GP) ; Generalized polarization ; (ROI) ; Region of Interest
- 刊名：Biochimica et Biophysica Acta (BBA)/General Subjects
- 出版年：July 2014
- 年：2014
- 卷：1840
- 期：7
- 页码：2192-2202
- 全文大小：2084 K
文摘
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225">Noise-induced OHC dysfunction is triggered by reactive oxygen species (ROS) overload.
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ROS overload affects membrane structural organization through lipid peroxidation.
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Noise-induced NAD(P)H oxidation is more pronounced in outer row OHCs.
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Lipid peroxidation is linked to decrease of OHC plasma membrane fluidity.
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Therapeutic intervention may target NAD(P)H redox state and lipid peroxidation.