Adolescent exposure to methylphenidate impairs serial pattern learning in the serial multiple choice (SMC) task in adult rats
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- 作者：James D. Rowana ; jrowan@wesleyancollege.edu" class="auth_mail" title="E-mail the corresponding author ; Madison K. McCartya ; mkmccarty@wesleyancollege.edu" class="auth_mail" title="E-mail the corresponding author ; Shannon M.A. Kundeyb ; kundey@hood.edu" class="auth_mail" title="E-mail the corresponding author ; Crystal D. Osburna ; cdosburn@wesleyancollege.edu" class="auth_mail" title="E-mail the corresponding author ; Samantha M. Renaudc ; srenaud@kent.edu" class="auth_mail" title="E-mail the corresponding author ; Brian M. Kelleyd ; bkelleyphd@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Amanda Willey Matousheke ; awilley@bluefieldstate.edu" class="auth_mail" title="E-mail the corresponding author ; Stephen B. Fountainc ; sfountai@kent.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Methylphenidate ; Ritalin ; Adolescent Exposure ; Sequential Behavior ; Serial Pattern Learning ; Serial Multiple Choice Task ; Phrasing ; Chunking ; Rats
- 刊名：Neurotoxicology and Teratology
- 出版年：2015
- 出版时间：September-October 2015
- 年：2015
- 卷：51
- 期：Complete
- 页码：21-26
- 全文大小：695 K
文摘
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We examined deficits in adult sequential learning after adolescent methylphenidate exposure.
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Adolescent methylphenidate impaired adult multiple-item learning.
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Adolescent methylphenidate impaired adult S–R and serial position learning.
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Adolescent methylphenidate did not impair adult rule learning.
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Impairments persisted into adulthood at least a month after methylphenidate exposure ended.