mRNA Cap Methylation in Pluripotency and Differentiation
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- 作者：Laura Grasso1 ; 8 ; Olga Suska1 ; 8 ; Lindsay Davidson2 ; Thomas Gonatopoulos-Pournatzis6 ; Ritchie Williamson7 ; Lize Wasmus3 ; Simone Wiedlich4 ; Mark Peggie4 ; Marios P. Stavridis5 ; Victoria H. Cowling1 ; 3 ; v.h.cowling@dundee.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：2 August 2016
- 年：2016
- 卷：16
- 期：5
- 页码：1352-1365
- 全文大小：3850 K
文摘
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The mRNA cap methyltransferase RNMT-RAM is highly expressed in embryonic stem cells
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RNMT-RAM is important for the expression of pluripotency-associated genes
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During neural differentiation, the cap methyltransferase activator RAM is repressed
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Repression of RAM contributes to upregulation of neural genes and neural morphology