Unique cistrome defined as CsMBE is strictly required for Nrf2-sMaf heterodimer function in cytoprotection
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- 作者：Akihito Otsukia ; Mikiko Suzukib ; suzukimikiko@med.tohoku.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Fumiki Katsuokac ; Kouhei Tsuchidaa ; Hiromi Sudaa ; Masanobu Moritaa ; Ritsuko Shimizud ; Masayuki Yamamotoa ; c ; masiyamamoto@med.tohoku.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Nrf2 ; Maf ; CsMBE ; MARE
- 刊名：Free Radical Biology and Medicine
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：91
- 期：Complete
- 页码：45-57
- 全文大小：4153 K
文摘
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Substitution of Ala-502 to Tyr renders the DNA-binding of Nrf2 similar to that of Maf.
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Sequence recognition of Nrf2A502Y shifts from CsMBE to MARE.
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Nrf2A502Y fails to induce major cytoprotective genes upon stress stimulation.
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Recognition of CsMBE by Nrf2-sMaf is required for the cytoprotective function.
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Nrf2A502Y mutant mice are susceptible to oxidative and xenobiotic stresses.