American Pediatric Academia: The Looming Question

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• 作者：Scott A. Rivkees ; Myron Genel
• 关键词：Central poststroke pain ; zonisamide ; thalamus ; low voltage– ; activated calcium channel
• 刊名：The Journal of Pediatrics
• 出版年：2007
• 出版时间：September 2007
• 年：2007
• 卷：151
• 期：3
• 页码：223-224
• 全文大小：107 K

文摘

We present 2 patients with severe and intractable central poststroke pain (CPSP) after right posterolateral thalamic infarcts who were successfully treated with zonisamide. The mechanism of action was presumed to be the suppression of overacting thalamic relay neurons by blockade of low voltage–activated calcium channel or by increasing gamma-aminobutyric acid (GABA) release. Zonisamide can be one of the therapeutic options for severe CPSP and might provide an insight into the pathogenesis of CPSP.<a name=""toc1"">a>

ass=""h3"">Perspective

The blockade of T-type VGCC or the increase in GABA release caused by zonisamide presumably suppresses abnormal activities of thalamic sensory neurons.