Crystal Structure of Hyaluronidase, a Major Allergen of Bee Venom
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- 作者：Markovic-Housley ; Zora ; Miglierini ; Giuliana ; Soldatova ; Lyudmila ; Rizkallah ; Pierre J. ; et. al.
- 关键词：allergen ; bee venom ; crystallography ; glycosidase family 56 ; hyaluronidase
- 刊名：Structure
- 出版年：2000
- 出版时间：October, 2000
- 年：2000
- 卷：8
- 期：10
- 页码：1025-1035
- 全文大小：809 K
文摘
Background: Hyaluronic acid (HA) is the most abundant glycosaminoglycan of vertebrate extracellular spaces and is specifically degraded by a β-1,4 glycosidase. Bee venom hyaluronidase (Hya) shares 30 % sequence identity with human hyaluronidases, which are involved in fertilization and the turnover of HA. On the basis of sequence similarity, mammalian enzymes and Hya are assigned to glycosidase family 56 for which no structure has been reported yet.