刊名:Biochemical and Biophysical Research Communications
出版年:2017
出版时间:22 January 2017
年:2017
卷:482
期:4
页码:1088-1094
全文大小:1009 K
卷排序:482
文摘
LPS stimulates LRRK2-mediated p53 phosphorylation and its nuclear localization. Phosphorylation of p53 by LRRK2 in microglia enhances TNFα expression. Microglial TNFα via LRRK2-induced p53 phosphorylation decreases neuronal survival.