Exposure to traffic-related air pollution and risk of development of childhood asthma: A systematic review and meta-analysis

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• 作者：Haneen Khreis^a ; ^{ts12hrk@leeds.ac.uk} ; ^{khreishaneen@gmail.com} ; Charlotte Kelly^a ; ^b ; James Tate^a ; Roger Parslow^c ; Karen Lucas^a ; Mark Nieuwenhuijsen^d ; ^e ; ^f
• 关键词：Asthma ; Childhood ; Traffic-related air pollution ; Meta-analysis ; Black carbon ; Transport policy
• 刊名：Environment International
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：100
• 期：Complete
• 页码：1-31
• 全文大小：1614 K
• 卷排序：100

文摘

Whether children's exposure to traffic-related air pollution contributes to their development of asthma is an unresolved question. We conducted a systematic review and a meta-analysis of observational studies published until 8 September 2016 investigating this question. Forty-one studies met our eligibility criteria and there was an epidemic growth in publications after 2014. Overall, there was notable variability in asthma definitions, TRAP exposure assessment and confounder adjustment. The meta-analysis showed positive and statistically significant associations between asthma onset and the exposure to BC, NO2, PM2.5 and PM10, with the least heterogeneity detected in the BC and PM analyses and the most detected in the NO2 and NOx analyses.