Interleukin-35 Limits Anti-Tumor Immunity
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- 作者：Meghan E. Turnis2 ; 5 ; 9 ; Deepali V. Sawant1 ; 2 ; 9 ; Andrea L. Szymczak-Workman2 ; 7 ; Lawrence P. Andrews1 ; Greg M. Delgoffe2 ; 6 ; Hiroshi Yano1 ; Amy J. Beres2 ; 8 ; Peter Vogel3 ; Creg J. Workman1 ; 2 ; Dario A.A. Vignali1 ; 2 ; 4 ; dvignali@pitt.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Immunity
- 出版年：2016
- 出版时间：16 February 2016
- 年：2016
- 卷：44
- 期：2
- 页码：316-329
- 全文大小：5446 K
文摘
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IL-35+ Treg cells, which have enhanced suppressive activity, are enriched in tumors
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IL-35 blockade or Treg cell-restricted deletion limits tumor growth in multiple models
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IL-35 limits antigen-specific T cell infiltration, effector function, and memory
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Treg-derived IL-35 promotes exhaustion of T cells within the tumor microenvironment